Endocrine Abstracts

TSH regulates thyroid function trough the receptor coupled to heterotrimeric G-protein composed of α, β and gamma subunits. The activation of α s /adenylyl cyclase mediated pathway accounts for most of TSH biological effects. TSH can also induce the other G-α protein mediated activities. Five different isoforms of β subunit have been described and it can be assumed that specific α-β combination are essential for functional differentiation of ...